Sofosbuvir is an NS5B RNA polymerase inhibitor that suppresses the replication (reproduction) of the hepatitis C virus. It is the newest drug of direct antiviral action. The drug acts directly on the hepatitis C virus (HCV). It blocks the main stages of virus reproduction. Used to treat patients with the first, second, third, and fourth genotypes of the virus. Today you can buy it with bitcoins.



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Indications for use

The drug is used to treat chronic hepatitis C in adults in combination with other antiviral drugs.

The drug is taken once a day at a dosage of 400 mg (1 tablet). The tablet is better not to chew, as it has a rich bitter taste. It is better to take medicine during food, washing down with plentiful water. Take the drug daily, at the same time.

Recommended treatment regimens for each genotype

EASL 2018 recommendations for treatment of HCV monoinfection or HIV / HCV co-infection in adult patients without cirrhosis. *
Hepatitis C treatment regimen with Sofosbuvir WITHOUT cirrhosis, genotypes 1,2,3,4,5,6
EASL 2018 recommendations for the treatment of HCV mono-infection or HIV / HCV co-infection in adult patients with compensated cirrhosis (Child-Pugh class A). *
Treatment regimens of hepatitis C with sofosbuvir with compensated cirrhosis, genotypes 1,2,3,4,5,6
* – In patients who have suffered a virological failure in the treatment of pegylated interferon and ribavirin, as well as in co-infection with hepatitis B, it is possible to change the duration of PVT according to the decision of the attending physician.

Side effects

In general, the drug is well tolerated and has no pronounced side effects. The most common ones are fatigue, headache and nausea. The severity of side effects increases with combination therapy with interferon and other antiviral drugs.

Adverse symptoms after using Sofosbuvir can be expressed as:

  • insomnia;
  • headaches;
  • migraine;
  • depression;
  • irritability;
  • seizures;
  • nausea, vomiting;
  • diarrhea or constipation;
  • dry mouth, etc.

There is no antidote to the drug, elimination of side effects is carried out symptomatically.
Starting therapy with Sofosbuvir, carefully monitor your health. Report to your doctor about the slightest deviation from the norm or adverse events.


The drug is used in combination with other antiviral agents only when the effectiveness exceeds possible complications. The drug should not be combined with Boceprevir or Telaprevir.
At a therapeutic dose of 400 mg per day, the drug does not affect the duration of the QT interval and does not cause irregularities in the work of the cardiovascular system.

Interaction with other drugs

The drug can not be taken:

  • children and teenagers under 18 years old;
  • during pregnancy;
  • during breastfeeding;
  • with increased sensitivity to the active substance.

These patients should not be treated with Sofosbuvir, since no clinical trials have been conducted for these groups.

Women of reproductive age should take the drug with caution, because at the moment the effect of Sofosbuvir on reproductive functions is not precisely established.
Elderly patients and patients with renal and hepatic insufficiency should be treated only under the close supervision of a physician. For mild renal and hepatic insufficiency, dosage change is not necessary.

Special instructions

Treatment should only be carried out under the close supervision of a doctor;
the drug is recommended to be taken in combination with other antiviral drugs;
monotherapy with Sofosbuvir is not recommended;
The recommended dose for adults is 400 mg per day (1 tablet) with meals;
do not reduce the daily dose of the drug;
the medicine has an unpleasant bitter taste, so the drug is better not to chew or divide into parts;
if vomiting occurs within two hours after taking the medicine, take an extra pill;
if vomiting occurs after two hours, an additional tablet is not required;
when the drug is not taken for any reason, immediately drink the missed pill. Next time you can take a pill at the usual time;
during treatment, refrain from activities that require speed of reaction and increased attention.

Release form

Oval tablets in a dosage of 400 mg. 28 tablets per pack.

Storage conditions

Keep the product in a dry, protected from the sun and out of the reach of children. Date of manufacture and shelf life are indicated on the packaging. Do not take the drug after the expiration date printed on the package. Store the drug should be at a temperature of from 15 to 30 ° C.

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